A cute graft-versus-host disease remains a major threat to a successful outcome after allogeneic hematopoietic cell transplantation. While improvements in treatment and supportive care have occurred, it is unknown whether these advances have resulted in improved outcome specifically among those diagnosed with acute graft-versus-host disease. We examined outcome following diagnosis of grade II-IV acute graft-versus-host disease according to time period, and explored effects according to original graft-versus-host disease prophylaxis regimen and maximum overall grade of acute graft-versus-host disease. Between 1999 and 2012, 2,905 patients with acute myeloid leukemia (56%), acute lymphoblastic leukemia (30%) or myelodysplastic syndromes (14%) received a sibling (24%) or unrelated donor (76%) blood (66%) or marrow (34%) transplant and developed grade II-IV acute graft-versus-host disease (n=497 for 1999-2001, n=962 for 2002-2005, n=1,446 for 2006-2010). The median (range) follow-up was 144 (4-174), 97 (4-147) and 60 (8-99) months for 1999-2001, 2002-2005, and 2006-2010, respectively. Among the cohort with grade II-IV acute graft-versus-host disease, there was a decrease in the proportion of grade III-IV disease over time with 56%, 47%, and 37% for 1999-2001, 2002-2005, and 2006-2012, respectively (P
Khoury, Hanna J.; Wang, Tao; Hemmer, Michael T.; Couriel, Daniel; Alousi, Amin; Cutler, Corey; Aljurf, Mahmoud; Antin, Joseph H; Ayas, Mouhab; Battiwalla, Minoo; Cahn, Jean-Yves; Cairo, Mitchell; Chen, Yi-Bin; Gale, Robert Peter; Hashmi, Shahrukh; Hayashi, Robert J.; Jagasia, Madan; Juckett, Mark; Kamble, Rammurti T.; Kharfan-Dabaja, Mohamed; Litzow, Mark; Majhail, Navneet; Miller, Alan; Nishihori, Taiga; Qayed, Muna; Schoemans, Helene; Schouten, Harry C.; Socie, Gerard; Storek, Jan; Verdonck, Leo; Vij, Ravi; Wood, William A.; Yu, Lolie; Martino, Rodrigo; Carabasi, Matthew; Dandoy, Christopher; Gergis, Usama; Hematti, Peiman; Solh, Melham; Jamani, Kareem; Lehmann, Leslie; Savani, Bipin; Schultz, Kirk R.; Wirk, Baldeep M.; Spellman, Stephen; Arora, Mukta; and Pidala, Joseph, "Improved survival after acute graft-versus-host disease diagnosis in the modern era." (2017). Department of Medical Oncology Faculty Papers. Paper 64.
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