REFINE: A Database of Linked Clinical Data and Genomic Biomarkers in Renal Cell Carcinoma Patients Receiving Immunotherapy-Based Treatment Regimens

Authors

Jeffrey Zhong
Albert Jang
Bashar Abuqayas
Arnab Basu
David Benjamin
Vineel Bhatlapenumarthi
Mehmet Asim Bilen
Dhvani Buch
Mark Chang
Erica Chin
Sourat Darabi
Nagendra Dhanikonda
Pooja Ghatalia
Claud Grigg
Abby Grier
Tanya Jindal
Joannah Jung
Deepak Kilari
Hamsa Kumar
Suzanna Lee
Brittany Neelands
Chinmayi Pandya
Jeff Pawalek
Jaimee Staggers
Ahmet Yildirim
Yousef Zakharia
Kevin Zarrabi, Thomas Jefferson UniversityFollow
Michael Zimmerman, Thomas Jefferson UniversityFollow
George Sledge
David Spetzler
Andrew Elliott
Rana McKay
Pedro Barata

Document Type

Article

Publication Date

6-4-2025

Comments

This article is the author's final published version in Oncologist, Volume 30, Issue 6, June 2025, oyaf135.

The published version is available at https://doi.org/10.1093/oncolo/oyaf135.

Copyright © The Author(s) 2025

Abstract

The REnal cancer consortium for Focused Investigation of Novel biomarkers and Expression (REFINE) consortium represents an important initiative in integrating clinical data with molecular sequencing in patients with advanced renal cell carcinoma (RCC) treated with immunotherapy-based approaches. By leveraging real-world evidence and genomic analysis, this consortium aims to explore putative predictive biomarkers with the potential to inform personalized treatment strategies. Findings from the REFINE database may further contribute to our understanding of disease courses of immunotherapy-based approaches for various molecular subtypes of RCC, associations of race and ethnicity with RCC treatment and outcomes with representation of patient populations underrepresented in clinical trials, and optimizing treatment sequencing.

Recommended Citation

Zhong, Jeffrey; Jang, Albert; Abuqayas, Bashar; Basu, Arnab; Benjamin, David; Bhatlapenumarthi, Vineel; Bilen, Mehmet Asim; Buch, Dhvani; Chang, Mark; Chin, Erica; Darabi, Sourat; Dhanikonda, Nagendra; Ghatalia, Pooja; Grigg, Claud; Grier, Abby; Jindal, Tanya; Jung, Joannah; Kilari, Deepak; Kumar, Hamsa; Lee, Suzanna; Neelands, Brittany; Pandya, Chinmayi; Pawalek, Jeff; Staggers, Jaimee; Yildirim, Ahmet; Zakharia, Yousef; Zarrabi, Kevin; Zimmerman, Michael; Sledge, George; Spetzler, David; Elliott, Andrew; McKay, Rana; and Barata, Pedro, "REFINE: A Database of Linked Clinical Data and Genomic Biomarkers in Renal Cell Carcinoma Patients Receiving Immunotherapy-Based Treatment Regimens" (2025). Department of Medical Oncology Faculty Papers. Paper 303.
https://jdc.jefferson.edu/medoncfp/303

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

40536267

Language

English