Increased Myositis and Possible Myocarditis in Melanoma Patients Treated with Immune Checkpoint Inhibitors in the COVID-19 Era

Authors

Allison L. Gradone, Thomas Jefferson UniversityFollow
Vincent T Ma
Alexi Vasbinder
Leslie A Fecher
Sarah Yentz
Salim S Hayek
Christopher D Lao

Document Type

Article

Publication Date

10-5-2024

Comments

This article is the author's final published version in Cancer Immunology, Immunotherapy, Volume 73, Issue 12, December 2024, Article number 259.

The published version is available at https://doi.org/10.1007/s00262-024-03803-5.

Copyright © 2024 The Author(s).

Abstract

BACKGROUND: Immune checkpoint inhibitor (ICI)-mediated myocarditis results in significant morbidity and mortality. At our institution, we noted an increased incidence of ICI-mediated myocarditis cases, leading to further investigation in our database of advanced melanoma patients treated with ICI therapy.

METHODS: A single-center, retrospective cohort analysis of patients with advanced melanoma identified cases of ICI-mediated myocarditis and myositis.

RESULTS: 366 patients with advanced melanoma received a dose of ICI from September 2014 to October 2019. Of these patients, there were 0 cases of ICI-mediated myocarditis (0%, 95% CI 0%-1.0%) and 2 cases of ICI-mediated myositis (0.55%, 95% CI 0.07%-1.96%). From November 2019 to December 2021, an additional 246 patients with advanced melanoma were identified. Of these patients, 10 (4.1%, 95% CI 1.97%-7.35%) developed ICI-mediated myocarditis and 10 developed ICI-mediated myositis.

CONCLUSION: Our study suggests an increase in prevalence of ICI-mediated muscle damage including myositis and myocarditis in the COVID-19 era. Differentiation of these patients and further risk stratification may allow for development of guidelines for nuanced management of this serious complication.

Recommended Citation

Gradone, Allison L.; Ma, Vincent T; Vasbinder, Alexi; Fecher, Leslie A; Yentz, Sarah; Hayek, Salim S; and Lao, Christopher D, "Increased Myositis and Possible Myocarditis in Melanoma Patients Treated with Immune Checkpoint Inhibitors in the COVID-19 Era" (2024). Department of Medical Oncology Faculty Papers. Paper 278.
https://jdc.jefferson.edu/medoncfp/278

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

Language

English