Document Type
Article
Publication Date
6-22-2024
Abstract
Objective: This study examines the C-reactive protein (CRP)/albumin ratio (CAR) as an inflammation-based prognostic score for predicting mortality in patients with Traumatic Brain Injury (TBI). Methods: We systematically searched the electronic databases PubMed, Embase, and Cochrane up to February 2024. Our inclusion criteria encompassed studies investigating CAR-predicted mor- tality in patients with TBI. We calculated the Odds Ratio (OR) and associated 95 % confidence intervals (95 % CI) using a random-effects model. Quality assessment of the included studies was appraised using a Newcastle–Ottawa scale. Results: A total of five studies comprising 1040 patients were included in this meta-analysis. The pooled results indicated that CAR was associated with mortality in patients with TBI (OR = 1.88, 95 % CI: 1.05–3.36, P < 0.0001). The findings of subgroup analysis indicated that the relationship between CAR and mortality in patients with TBI did not vary with the severity of the condition. Conclusions: CAR emerges as a valuable prognostic tool for mortality in patients with TBI, underscoring its potential role in early risk stratification and management strategies.
Recommended Citation
Liu, Yuyang; Tan, Yaheng; Wan, Jun; Chen, Qiwen; Zheng, Yuxin; Xu, Wenhao; Wang, Peng; Chong, Weelic; Yu, Xueying; and Zhang, Yu, "Association of C-Reactive Protein/Albumin Ratio With Mortality in Patients With Traumatic Brain Injury: A Systematic Review and Meta-Analysis" (2024). Department of Medical Oncology Faculty Papers. Paper 269.
https://jdc.jefferson.edu/medoncfp/269
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Language
English
Comments
This article is the author's final published version in Heliyon, Volume 10, Issue 13, July 2024, Article number e33460.
The published version is available at https://doi.org/10.1016/j.heliyon.2024.e33460.
Copyright © 2024 The Authors