Review of Cardiovascular Risk of Androgen Deprivation Therapy and the Influence of Race in Men with Prostate Cancer
Androgen deprivation therapy is the cornerstone of prostate cancer therapy. Recent studies have revealed an association between androgen deprivation therapy and cardiovascular adverse effects such as myocardial infarction and stroke. This review summarizes the available research on the cardiovascular risk of men using androgen deprivation therapy. We also discuss racial disparities surrounding both prostate cancer and cardiovascular disease, emphasizing the importance of biological/molecular and socioeconomic factors in assessing baseline risk in patients beginning androgen ablation. Based on the literature, we provide recommendations for monitoring patients who are at high risk for a cardiovascular adverse event while being treated on androgen deprivation therapy. This review aims to present the current research on androgen deprivation therapy and cardiovascular toxicity with an emphasis on racial disparities and provides a framework for clinicians to decrease the cardiovascular morbidity in men that are being treated with hormone therapy.
Fradin, James; Kim, Felix J.; Lu-Yao, Grace; Storozynsky, Eugene; and Kelly, William K., "Review of Cardiovascular Risk of Androgen Deprivation Therapy and the Influence of Race in Men with Prostate Cancer" (2023). Department of Medical Oncology Faculty Papers. Paper 235.
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This work is licensed under a Creative Commons Attribution 4.0 License.
This article is the author’s final published version in Cancers, Volume 15, Issue 8, April 2023, Article number 2316.
The published version is available at https://doi.org/10.3390/cancers15082316. Copyright © Fradin et al.