Phase II Study of Palbociclib (PD-0332991) in CCND1, 2, or 3 Amplification: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol Z1B
Purpose: Cyclin D/CDK4/6 is critical in controlling the G1 to S checkpoint. CCND, the gene encoding cyclin D, is known to be amplified in a variety of solid tumors. Palbociclib is an oral CDK4/6 inhibitor, approved in advanced breast cancer in combination with endocrine therapy. We explored the efficacy of palbociclib in patients with nonbreast solid tumors containing an amplification in CCND1, 2, or 3.
Patients and methods: Patients with tumors containing a CCND1, 2, or 3 amplification and expression of the retinoblastoma protein were assigned to subprotocol Z1B and received palbociclib 125 mg once daily for 21 days of a 28-day cycle. Tumor response was assessed every two cycles.
Results: Forty patients were assigned to subprotocol Z1B; 4 patients had outside assays identifying the CCND1, 2, or 3 amplification and were not confirmed centrally; 3 were ineligible and 2 were not treated (1 untreated patient was also ineligible), leaving 32 evaluable patients for this analysis. There were no partial responses; 12 patients (37.5%) had stable disease as best response. There were seven deaths on study, all during cycle 1 and attributable to disease progression. Median progression-free survival was 1.8 months. The most common toxicities were leukopenia (n = 21, 55%) and neutropenia (n = 19, 50%); neutropenia was the most common grade 3/4 event (n = 12, 32%).
Conclusions: Palbociclib was not effective at treating nonbreast solid tumors with a CCND1, 2, or 3 amplification in this cohort. These data do not support further investigation of single-agent palbociclib in tumors with CCND1, 2, or 3 amplification.
Clark, Amy S; Hong, Fangxin; Finn, Richard S; DeMichele, Angela M; Mitchell, Edith P.; Zwiebel, James; Arnaldez, Fernanda I; Gray, Robert J; Wang, Victoria; McShane, Lisa M; Rubinstein, Larry V; Patton, David; Williams, P Mickey; Hamilton, Stanley R; Copur, Mehmet S; Kasbari, Samer S; Thind, Ravneet; Conley, Barbara A; Arteaga, Carlos L; O'Dwyer, Peter J; Harris, Lyndsay N; Chen, Alice P; and Flaherty, Keith T, "Phase II Study of Palbociclib (PD-0332991) in CCND1, 2, or 3 Amplification: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol Z1B" (2023). Department of Medical Oncology Faculty Papers. Paper 234.
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This article is the author’s final published version in Clinical Cancer Research, Volume 29, Issue 8, April 2023, Pages 1477-1483.
The published version is available at https://doi.org/10.1158/1078-0432.CCR-22-2150. Copyright © Clark et al.