Document Type
Article
Publication Date
9-16-2022
Abstract
Arsenic is a crucial environmental metalloid whose high toxicity levels negatively impact human health. It poses significant health concerns to millions of people in developed and developing countries such as the USA, Canada, Bangladesh, India, China, and Mexico by enhancing sensitivity to various types of diseases, including cancers. However, how arsenic causes changes in gene expression that results in heinous conditions remains elusive. One of the proposed essential mechanisms that still has seen limited research with regard to causing disease upon arsenic exposure is the dysregulation of epigenetic components. In this review, we have extensively summarized current discoveries in arsenic-induced epigenetic modifications in carcinogenesis and angiogenesis. Importantly, we highlight the possible mechanisms underlying epigenetic reprogramming through arsenic exposure that cause changes in cell signaling and dysfunctions of different epigenetic elements.
Recommended Citation
Islam, Ranakul; Zhao, Lei; Wang, Yifang; Lu-Yao, Grace; and Liu, Ling-Zhi, "Epigenetic Dysregulations in Arsenic-Induced Carcinogenesis" (2022). Department of Medical Oncology Faculty Papers. Paper 208.
https://jdc.jefferson.edu/medoncfp/208
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Language
English
Comments
This article is the author's final published version in Cancers, Volume 14, Issue 18, Article number 4502.
The published version is available at https://doi.org/10.3390/cancers14184502. Copyright © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).