Document Type
Article
Publication Date
8-1-2014
Abstract
In primary biliary cirrhosis (PBC), the breach of tolerance that leads to active disease involves a disruption in several layers of control, including central tolerance, peripheral anergy, a "liver tolerance effect," and the action of T regulatory cells and their related cytokines. Each of these control mechanisms plays a role in preventing an immune response against self, but all of them act in concert to generate effective protection against autoimmunity without compromising the ability of the host immune system to mount an effective response to pathogens. At the same time, genetic susceptibility, environmental factors, including infection agents and xenobiotics, play important roles in breach of tolerance in the development of PBC.
Recommended Citation
Wang, Lifeng; Wang, Fu-Sheng; Chang, Christopher; and Gershwin, M Eric, "Breach of tolerance: primary biliary cirrhosis." (2014). Department of Medical Genetics Faculty Papers. Paper 9.
https://jdc.jefferson.edu/medgenfp/9
PubMed ID
25057953
Comments
This article has been peer reviewed. It was published in: Seminars in Liver Disease.
Volume 34, Issue 3, August 2014, Pages 297-317.
The published version is available at DOI: 10.1055/s-0034-1383729
Copyright © 2014 by Thieme Medical Publishers, Inc.