Document Type
Article
Publication Date
3-7-2026
Abstract
UNLABELLED: Laparoscopic renal denervation (RDN) represents a specialized approach for hypertension, particularly when conventional methods face limitations. While catheter-based RDN has demonstrated significant efficacy in recent large-scale clinical trials and has been integrated into international guidelines, its effectiveness can be constrained by complex renal anatomy or incomplete ablation. We developed a novel laparoscopic RDN system, comprising an integrated radiofrequency (RF) clamp, RF generator, and cooling pump, to achieve more controlled adventitial ablation. This study aims to evaluate the safety, feasibility, and optimal parameters of this new system in a preclinical swine model. Sixteen pigs were divided into an immediate group (
SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1038/s41598-026-43593-7.
Recommended Citation
Zhao, Linwei; Yang, Wei; Zhu, Binbin; Liu, Yahui; Tian, Peng; Guo, Xinyu; Dong, Yang; Fan, Zhiqiang; Li, Huiping; Feng, Yu; Zhu, Lijie; Bai, Minfu; Zhao, Qiuping; Zhang, Xingkun; Si, Chenchen; Cheng, Qianqian; Yan, Gan-Xin; and Gao, Chuanyu, "A Novel Laparoscopic Renal Denervation System in a Preclinical Swine Model" (2026). Department of Medicine Faculty Papers. Paper 556.
https://jdc.jefferson.edu/medfp/556
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
41795018
Language
English
Comments
This article is the author's final published version in Scientific Reports, Volume 16, Issue 1, Article Number 10533.
The published version is available at https://doi.org/10.1038/s41598-026-43593-7. Copyright © The Author(s).