Document Type
Article
Publication Date
11-27-2025
Abstract
The gastrointestinal endothelin system regulates vital processes including motility, secretion, sensation, and inflammation. Endothelin-1 acts via endothelin A and B receptors expressed on diverse intestinal cells. Dysregulation of endothelin signaling underlies common gastrointestinal disorders such as inflammatory bowel disease and irritable bowel syndrome. Aberrant endothelin-1 production and endothelin A receptor activation contribute to the inflammation, pain hypersensitivity, impaired epithelial function, and smooth muscle hypercontractility characteristic of these diseases. Endothelin receptor antagonists may provide therapies for managing related symptoms. However, knowledge gaps exist regarding cell-specific signaling pathways, regulatory factors, and precise roles in intestinal pathologies. Elucidating these details and translating insights into improved endothelin-targeted treatments could enable novel strategies for restoring homeostasis and improving patient outcomes. Advancing understanding of tissue-specific endothelin system functions represents a promising research avenue for unraveling disease mechanisms and developing new therapies for gastrointestinal disorders involving dysfunction of this regulatory axis.
Recommended Citation
Singh, Arjun and Singh, Rajvir, "The Gastrointestinal Endothelin System: Receptors, Cellular Actions, and Involvement in Gastrointestinal Disorders" (2025). Department of Medicine Faculty Papers. Paper 538.
https://jdc.jefferson.edu/medfp/538
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.
PubMed ID
41473484
Language
English
Comments
This article is the author’s final published version in Przeglad Gastroenterologiczny, Volume 20, Issue 4, 2025, Pages 372-381.
The published version is available at https://doi.org/10.5114/pg.2025.156471. Copyright © Termedia Sp. z o. o..