Document Type
Article
Publication Date
4-28-2021
Abstract
BACKGROUND: COVID-19 is a respiratory infectious disease caused by SARS-CoV-2, and cardiovascular damage is commonly observed in affected patients. We sought to investigate the effect of SARS-CoV-2 infection on cardiac injury and hypertension during the current coronavirus pandemic.
STUDY DESIGN AND METHODS: The clinical data of 366 hospitalized COVID-19-confirmed patients were analyzed. The clinical signs and laboratory findings were extracted from electronic medical records. Two independent, experienced clinicians reviewed and analyzed the data.
RESULTS: Cardiac injury was found in 11.19% (30/268) of enrolled patients. 93.33% (28/30) of cardiac injury cases were in the severe group. The laboratory findings indicated that white blood cells, neutrophils, procalcitonin, C-reactive protein, lactate, and lactic dehydrogenase were positively associated with cardiac injury marker. Compared with healthy controls, the 190 patients without prior hypertension have higher AngⅡ level, of which 16 (8.42%) patients had a rise in blood pressure to the diagnostic criteria of hypertension during hospitalization, with a significantly increased level of the cTnI, procalcitonin, angiotensin-II (AngⅡ) than those normal blood pressure ones. Multivariate analysis indicated that elevated age, cTnI, the history of hypertension, and diabetes were independent predictors for illness severity. The predictive model, based on the four parameters and gender, has a good ability to identify the clinical severity of COVID-19 in hospitalized patients (area under the curve: 0.932, sensitivity: 98.67%, specificity: 75.68%).
CONCLUSION: Hypertension, sometimes accompanied by elevated cTnI, may occur in COVID-19 patients and become a sequela. Enhancing Ang II signaling, driven by SARS-CoV-2 infection, might play an important role in the renin-angiotensin system, and consequently lead to the development of hypertension in COVID-19.
Recommended Citation
Chen, Ganxiao; Li, Xun; Gong, Zuojiong; Xia, Hao; Wang, Yao; Wang, Xuefen; Huang, Yan; Barajas-Martinez, Hector; and Hu, Dan, "Hypertension as a sequela in patients of SARS-CoV-2 infection." (2021). Department of Medicine Faculty Papers. Paper 294.
https://jdc.jefferson.edu/medfp/294
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
33909683
Language
English
Comments
This article is the author's final; published version in PLoS One, Volume 16, Issue 4 April 2021, April 2021, Article number e0250815.
The published version is available at https://doi.org/10.1371/journal.pone.0250815
Copyright © 2021 Chen et al
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.