Document Type

Article

Publication Date

6-20-2019

Comments

This article is the author's final version prior to publication in Blood, Volume 133, Issue 25, June 2019, Pages 2633-2634.

The published version is available at https://doi.org/10.1182/blood.2019000811. Copyright © The American Society of Hematology

Abstract

In this issue ofBlood, Volz et al establish a potential antitumor strategy byexploiting the selective requirement for platelets to maintain vascular in-tegrity within the tumor microenvironment.1Their work demonstrates, forthefirst time, that functional inhibition of platelet-specific surface receptorglycoprotein (GP) VI, using F(ab9)2fragments to avoid platelet clearance,increases intratumoral hemorrhage and concomitant tumor cell apoptosis, aswell as enhanced accumulation of chemotherapeutic drugs. These effectswork additively to inhibit tumor growth, achieving results similar to thoseachieved by platelet depletion.

PubMed ID

31221792

Language

English

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