Document Type
Article
Publication Date
5-11-2018
Abstract
Under inflammatory conditions, inflammatory cells release reactive oxygen species (ROS) and reactive nitrogen species (RNS) which cause DNA damage. If not appropriately repaired, DNA damage leads to gene mutations and genomic instability. DNA damage checkpoint factors (DDCF) and DNA damage repair factors (DDRF) play a vital role in maintaining genomic integrity. However, how DDCFs and DDRFs are modulated under physiological and pathological conditions are not fully known. We took an experimental database analysis to determine the expression of 26 DNA DD
Recommended Citation
Zeng, Huihong; Nanayakkara, Gayani K; Shao, Ying; Fu, Hangfei; Sun, Yu; Cueto, Ramon; Yang, William Y; Yang, Qian; Sheng, Haitao; Wu, Na; Wang, Luqiao; Yang, Wuping; Chen, Hongping; Shao, Lijian; Sun, Jianxin; Qin, Xuebin; Park, Joon Y.; Drosatos, Konstantinos; Choi, Eric T.; Zhu, Qingxian; Wang, Hong; and Yang, Xiaofeng, "DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses-Inflammations and Cancers Can Have High Genomic Risks." (2018). Department of Medicine Faculty Papers. Paper 238.
https://jdc.jefferson.edu/medfp/238
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
29867559
Language
English
Comments
This article has been peer reviewed. It is the author’s final published version in Frontiers in Physiology, Volume 9, Issue MAY, May 2018, Article number 516.
The published version is available at https://doi.org/10.3389/fphys.2018.00516. Copyright © Zeng et al.