Multiple Metabolic Hits Converge on CD36 as Novel Mediator of Tubular Epithelial Apoptosis in Diabetic Nephropathy

Authors

Katalin Susztack, Mt. Sinai School of Medicine
Emilio Ciccone, Thomas Jefferson UniversityFollow
Peter McCue, Thomas Jefferson UniversityFollow
Kumar Sharma, Thomas Jefferson UniversityFollow
Erwin Böttinger, Mt. Sinai School of MedicineFollow

Document Type

Article

Publication Date

February 2005

Comments

This article has been peer-reviewed. It was originally published in PLoS Medicine 2(2): e45, February 2005.

Abstract

Diabetic nephropathy (DNP) is a common complication of type 1 and type 2 diabetes mellitus and the most common cause of kidney failure. While DNP manifests with albuminuria and diabetic glomerulopathy, its progression correlates best with tubular epithelial degeneration (TED) and interstitial fibrosis. However, mechanisms leading to TED in DNP remain poorly understood.

Recommended Citation

Susztack, Katalin; Ciccone, Emilio; McCue, Peter; Sharma, Kumar; and Böttinger, Erwin, "Multiple Metabolic Hits Converge on CD36 as Novel Mediator of Tubular Epithelial Apoptosis in Diabetic Nephropathy" (2005). Department of Medicine Faculty Papers. Paper 2.
https://jdc.jefferson.edu/medfp/2