Notching early repolarization pattern in inferior leads increases risk of ventricular tachyarrhythmias in patients with acute myocardial infarction: a meta-analysis.

Authors

Zhiwei Zhang, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University
Konstantinos P Letsas, Second Department of Cardiology, Laboratory of Cardiac Electrophysiology, Evangelismos General Hospital of Athens
Yajuan Yang, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University
Panagiotis Korantzopoulos, First Department of Cardiology, University of Ioannina Medical School
Guangping Li, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University
Gan-Xin Yan, Lankenau Institute for Medical Research and Lankenau Medical Center; Jefferson Medical College; First Affiliated Hospital, Medical School of Xian Jiaotong UniversityFollow
Tong Liu, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University

Document Type

Article

Publication Date

11-2-2015

Comments

This article has been peer reviewed. It was published in: Scientific Reports.

Volume 5, 2 November 2015, Article number 15845.

The published version is available at DOI: 10.1038/srep15845

Copyright © 2015, Macmillan Publishers Limited

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Abstract

The aim of this of this meta-analysis was to examine the potential association between certain early repolarization (ER) characteristics and ventricular tachyarrhythmias (VTAs) in patients with acute myocardial infarction (AMI). We searched PubMed, Embase and Web of Science databases for records published until December 2014. Of the 658 initially identified records, 7 studies with a total of 1,565 patients (299 with ER and 1,266 without ER) were finally analyzed. Overall, patients with ER displayed a higher risk of VTAs following AMI compared to patients without ER [odds ratio (OR): 3.75, 95% CI: 2.62-5.37, p < 0.00001]. Subgroup analyses showed that the diagnosis of ER prior to AMI onset is a better predictor of VTAs (OR: 5.70, p < 0.00001) compared to those diagnosed after AMI onset (OR: 2.60, p = 0.00001). Remarkably, a notching morphology was a significant predictor of VTAs compared to slurring morphology (OR: 3.85, p = 0.002). Finally, an inferior ER location (OR: 8.85, p < 0.00001) was significantly associated with increased risk of VTAs in AMI patients. In conclusion, our meta-analysis suggests that ER pattern is associated with greater risk of VTAs in patients with AMI. A notched ER pattern located in inferior leads confers the highest risk for VTAs in AMI.

Recommended Citation

Zhang, Zhiwei; Letsas, Konstantinos P; Yang, Yajuan; Korantzopoulos, Panagiotis; Li, Guangping; Yan, Gan-Xin; and Liu, Tong, "Notching early repolarization pattern in inferior leads increases risk of ventricular tachyarrhythmias in patients with acute myocardial infarction: a meta-analysis." (2015). Department of Medicine Faculty Papers. Paper 136.
https://jdc.jefferson.edu/medfp/136

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

26521690