Document Type
Article
Publication Date
1-9-2024
Abstract
Multiple myeloma (MM) is characterized by the neoplastic proliferation of plasma cells, leading to the production of monoclonal immunoglobulins. High-dose chemotherapy with autologous stem cell transplant has been used in the treatment of patients with MM (1). Melphalan (L-phenylalanine nitrogen mustard) is one of the most effective chemotherapeutic drugs in the treatment of MM (2). The side effects of melphalan include anemia, nausea, vomiting, allergic reactions, oral ulcers, nephrotoxicity, and arrhythmia at high doses (3). The effect of this drug on cardiac mechanics and heart damage is not well established, as previous studies have only focused on the electrocardiographic and metabolic effects of this drug.
Recommended Citation
Mirsafaee, Liaosadat; Dehghani Firouzabadi, Mohammad; Parkhideh, Sayeh; Vahidnezhad, Hassan; Dehghani Firouzabadi, Fatemeh; Arab, Maryam; Yousem, David M.; and Karvandi, Mersedeh, "Correlation between Melphalan Chemotherapy with Longitudinal Global Strain Indices of the Left Ventricle in Multiple Myeloma Patients: A Velocity Vector Imaging (VVI) Echocardiography Study" (2024). Jefferson Institute of Molecular Medicine Papers and Presentations. Paper 18.
https://jdc.jefferson.edu/jimmfp/18
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
PubMed ID
38463920
Language
English
Comments
This article is the author’s final published version in Caspian Journal of Internal Medicine, Volume 15, Issue 1, January 2024, Pages 199-201.
The published version is available at https://doi.org/10.22088/cjim.15.1.25. Copyright © The Author(s).