Use of Apheresis and Insulin for Hypertriglyceridemia-induced Pancreatitis and Diabetic Ketoacidosis

Authors

Drew Kirk, PharmD, Thomas Jefferson UniversityFollow
Cara McDaniel, PharmD, BCPS, Thomas Jefferson UniversityFollow
Rohit A. Moghe, PharmD, MSPH, CDE, Thomas Jefferson UniversityFollow

Document Type

Poster

Publication Date

2013

Abstract

CLINICAL RELEVANCE

• Acute pancreatitis (AP) is a common gastrointestinal disease that may result in multiple organ failure and death¹

– Gallstones & alcohol are the most common causes of AP¹

– Hypertriglyceridemia (HTG) causes 1-4% of cases, and should be suspected if triglycerides (TG) are > 1,000 mg/dL in the absence of gallstones or history of significant alcohol use¹

– Clinical management of hypertriglyceridemia-induced pancreatitis (HTGP) is based primarily on anecdotal evidence and case reports

• Concurrent diabetic ketoacidosis (DKA) and AP have been described in the literature

– DKA may be a risk factor for AP, but it is uncertain if AP triggers DKA or vice-versa²

– The optimal management of patients that present with AP, HTG, and DKA is unknown^2,3

Recommended Citation

Kirk, PharmD, Drew; McDaniel, PharmD, BCPS, Cara; and Moghe, PharmD, MSPH, CDE, Rohit A., "Use of Apheresis and Insulin for Hypertriglyceridemia-induced Pancreatitis and Diabetic Ketoacidosis" (2013). Pharmacy Presentations, Posters, and Grand Rounds. Paper 4.
https://jdc.jefferson.edu/jeffpharmacypresgr/4