Neuroleptic Malignant Syndrome: Review, Diagnostic Critique

Authors

Khurram K. Durrani M.D., Stanford University School of Medicine; Saint Elizabeths Residency Training Program, Washington, D.C.

Abstract

Neuroleptic malignant syndrome (NMS) can be defined as an idiosyncratic and potentially fatal reaction to neuroleptic agents that consists of fever, mental status changes, muscle rigidity, autonomic dysfunction, respiratory distress and rhabdomyolysis. The pathogenesis of NMS is still not fully understood. The diagnosis presents a challenge and the diagnostic criteria need further refinement. The presentation and course of NMS are quite variable and can range from a progressive, fulminating, downhill course to a relatively benign and self-limiting course. Despite great improvements in the management of the syndrome, prevention and early diagnosis are the most important aspects of treatment.

Recommended Citation

Durrani, Khurram K. M.D. (2002) "Neuroleptic Malignant Syndrome: Review, Diagnostic Critique," Jefferson Journal of Psychiatry: Vol. 17: Iss. 1, Article 3.
DOI: https://doi.org/10.29046/JJP.017.1.002
Available at: https://jdc.jefferson.edu/jeffjpsychiatry/vol17/iss1/3