When Delivery Matters: Diffuse Coronary Vasospasm with Continuous, but Not Bolus, 5-FU Infusion

Authors

• Muhammad SabriFollow
• Zinya TalukderFollow
• Angad BediFollow
• Sung-Hae ChoFollow

Document Type

Article

Publication Date

12-31-2025

Comments

This article is the author's final published version in Global Cardiology Science and Practice, Volume 2025, Issue 6, 2025, Article number e202561.

The published version is available at https://doi.org/10.21542/gcsp.2025.61. Copyright ©2025 The Author(s), licensee Magdi Yacoub Institute

Abstract

5-Fluorouracil (5-FU) is a fluorinated pyrimidine chemotherapy analogue used to treat various gastrointestinal solid malignancy. It is known to be associated with cardiotoxicity. Here, we present a case of 58-year-old male with mucinous adenocarcinoma of the sigmoid colon who experienced global coronary vasospasm in setting of continuous 5-FU infusion refractory to prophylactic antianginal treatment. However, he was asymptotic when given bolus of 5-FU. Our case highlights the difference in toxicity between continuous and bolus 5-FU therapy and emphasizes the need for further research in the pathophysiology and treatment of cardiotoxicity related to 5-FU therapy.

Recommended Citation

Sabri, Muhammad; Talukder, Zinya; Bedi, Angad; and Cho, Sung-Hae, "When Delivery Matters: Diffuse Coronary Vasospasm with Continuous, but Not Bolus, 5-FU Infusion" (2025). Division of Internal Medicine Faculty Papers & Presentations. Paper 77.
https://jdc.jefferson.edu/internalfp/77

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

41978898

Language

English