Hyperdynamic Left Ventricular Ejection Fraction Is Associated With Higher Mortality in COVID-19 Patients
Study objective: To compare the characteristics and outcomes of COVID-19 patients with a hyperdynamic LVEF (HDLVEF) to those with a normal or reduced LVEF.
Design: Retrospective study.
Setting: Rush University Medical Center.
Participants: Of the 1682 adult patients hospitalized with COVID-19, 419 had a transthoracic echocardiogram (TTE) during admission and met study inclusion criteria. Interventions: Participants were divided into reduced (LVEF < 50%), normal (≥50% and <70%), and hyper- dynamic (≥70%) LVEF groups.
Main outcome measures: LVEF was assessed as a predictor of 60-day mortality. Logistic regression was used to adjust for age and BMI.
Results: There was no difference in 60-day mortality between patients in the reduced LVEF and normal LVEF groups (adjusted odds ratio [aOR] 0.87, p = 0.68). However, patients with an HDLVEF were more likely to die by 60 days compared to patients in the normal LVEF group (aOR 2.63 [CI: 1.36–5.05]; p < 0.01). The HDLVEF group was also at higher risk for 60-day mortality than the reduced LVEF group (aOR 3.34 [CI: 1.39–8.42]; p < 0.01).
Conclusion: The presence of hyperdynamic LVEF during a COVID-19 hospitalization was associated with an increased risk of 60-day mortality, the requirement for mechanical ventilation, vasopressors, and intensive care unit.
Rahman, Annas; Ruge, MD, Max; Hlepas, Alex; Nair, Batha; Gomez, Joanne; du Fey de Lavallaz, Jeanne; Fugar, Setri; Jahan, Nusrat; Volgman, Annabelle Santos; Williams, Kim A.; Rao, Anupama; Marinescu, Karolina; and Suboc, Tisha, "Hyperdynamic Left Ventricular Ejection Fraction Is Associated With Higher Mortality in COVID-19 Patients" (2022). Division of Internal Medicine Faculty Papers & Presentations. Paper 63.
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This article is the author's final published version in American Heart Journal Plus: Cardiology Research and Practice, Volume 14, February 2022, Article number 100134.
The published version is available at https://doi.org/10.1016/j.ahjo.2022.100134. Copyright © 2022 The Authors. Published by Elsevier Inc.