Title

Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review.

Authors

Maham Farshidpour, Banner University of Medical Center
Monjur Ahmed, Thomas Jefferson UniversityFollow
Shilpa Junna, Banner University of Medical Center
Juanita L. Merchant, Banner University of Medical Center

Document Type

Article

Publication Date

1-15-2021

Comments

This article is the author’s final published version in World Journal of Gastrointestinal Oncology, Volume 13, Issue 1, January 2021, Pages 1-15.

The published version is available at https://doi.org/10.4251/WJGO.V13.I1.1. Copyright © Farshidpour et al.

Abstract

Gastrointestinal (GI) cancers are one of the most common malignancies worldwide, with high rates of morbidity and mortality. Myeloid-derived suppressor cells (MDSCs) are major components of the tumor microenvironment (TME). MDSCs facilitate the transformation of premalignant cells and play roles in tumor growth and metastasis. Moreover, in patients with GI malignancies, MDSCs can lead to the suppression of T cells and natural killer cells. Accordingly, a better understanding of the role and mechanism of action of MDSCs in the TME will aid in the development of novel immune-targeted therapies.

Recommended Citation

Farshidpour, Maham; Ahmed, Monjur; Junna, Shilpa; and Merchant, Juanita L., "Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review." (2021). Division of Internal Medicine Faculty Papers & Presentations. Paper 38.
https://jdc.jefferson.edu/internalfp/38

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

PubMed ID

33510845

Language

English