Document Type
Article
Publication Date
1-15-2021
Abstract
Gastrointestinal (GI) cancers are one of the most common malignancies worldwide, with high rates of morbidity and mortality. Myeloid-derived suppressor cells (MDSCs) are major components of the tumor microenvironment (TME). MDSCs facilitate the transformation of premalignant cells and play roles in tumor growth and metastasis. Moreover, in patients with GI malignancies, MDSCs can lead to the suppression of T cells and natural killer cells. Accordingly, a better understanding of the role and mechanism of action of MDSCs in the TME will aid in the development of novel immune-targeted therapies.
Recommended Citation
Farshidpour, Maham; Ahmed, Monjur; Junna, Shilpa; and Merchant, Juanita L., "Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review." (2021). Division of Internal Medicine Faculty Papers & Presentations. Paper 38.
https://jdc.jefferson.edu/internalfp/38
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
PubMed ID
33510845
Language
English
Comments
This article is the author’s final published version in World Journal of Gastrointestinal Oncology, Volume 13, Issue 1, January 2021, Pages 1-15.
The published version is available at https://doi.org/10.4251/WJGO.V13.I1.1. Copyright © Farshidpour et al.