BACKGROUND: Maternal nutrition in preconception and early pregnancy influences fetal growth. Evidence for effects of prenatal maternal nutrition on early child development (ECD) in low-income and middle-income countries is limited.
OBJECTIVES: To examine impact of maternal nutrition supplementation initiated prior to or during pregnancy on ECD, and to examine potential association of postnatal growth with ECD domains.
DESIGN: Secondary analysis regarding the offspring of participants of a maternal multicountry, individually randomised trial.
SETTING: Rural Democratic Republic of the Congo, Guatemala, India and Pakistan.
PARTICIPANTS: 667 offspring of Women First trial participants, aged 24 months.
INTERVENTION: Maternal lipid-based nutrient supplement initiated preconceptionally (arm 1, n=217), 12 weeks gestation (arm 2, n=230) or not (arm 3, n=220); intervention stopped at delivery.
MAIN OUTCOME MEASURES: The INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) cognitive, language, gross motor, fine motor, positive and negative behaviour scores; visual acuity and contrast sensitivity scores and auditory evoked response potentials (ERP). Anthropometric z-scores, family care indicators (FCI) and sociodemographic variables were examined as covariates.
RESULTS: No significant differences were detected among the intervention arms for any INTER-NDA scores across domains, vision scores or ERP potentials. After adjusting for covariates, length-for-age z-score at 24 months (LAZ
CONCLUSIONS: Prenatal maternal nutrition supplementation was not associated with any neurodevelopmental outcomes at age 2 years. Maternal education, family environment and LAZ
TRIAL REGISTRATION NUMBER: NCT01883193.
Recommended CitationFernandes, Michelle; Krebs, Nancy F.; Westcott, Jamie; Tshefu, Antoinette; Lokangaka, Adrien; Bauserman, Melissa; Garcés, Ana L.; Figueroa, Lester; Saleem, Sarah; Aziz, Sumera A.; Goldenberg, Robert L.; Goudar, Shivaprasad S.; Dhaded, Sangappa M.; Derman, Richard J.; Kemp, Jennifer F.; Koso-Thomas, Marion; Sridhar, Amaanti; McClure, Elizabeth M.; and Hambidge, K. Michael, "Neurodevelopment, Vision and Auditory Outcomes at Age 2 Years in Offspring of Participants in the ‘Women First’ Maternal Preconception Nutrition Randomised Controlled Trial" (2023). Global Health Articles. Article 29.
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