Granular cell tumors (GCTs) are rare, benign mesenchymal tumors of Schwann cell origin. Since they were originally described by Abrikossoff in 1926,most GCTs have been described in the dermis, oral area, or subcutaneous tissue of the chest and arms. Only 5%-9% of reported cases have involved the gastrointestinal tract and fewer than 1% of cases have occurred in the biliary tract.Tumors involving the bile duct are difficult to distinguish radiographically from more common etiologies of biliary stricturing, and a tissue diagnosis is difficult to obtain endoscopically. Diagnosis and treatment is most often made via surgical resection.
Chopade, MBBS, Tripti R.; Smith, MD, Colin L.; Maley, MD, Warren R.; Siddiqui, MD, Ali A.; and Sass, MD, David A., "Granular cell tumor of the common hepatic duct as an unusual cause of jaundice in a hepatitis C patient: looking beyond the tip of the iceberg!" (2015). Division of Gastroenterology and Hepatology Faculty Papers. Paper 30.