Document Type


Publication Date

Fall 11-2008


This article has been peer reviewed. It is the authors' final version prior to publication in Journal of the American Board of Family Medicine Volume 21, Issue 6, November 2008, Pages 577-579. The published version is available at . DOI: 10.3122/jabfm.2008.06.080103. Copyright © American Board of Family Medicine.


Angioedema is a side effect that is often associated with use of angiotensin converting enzyme inhibitor medications. These medications result in increased levels of circulating bradykinins. This case illustrates the result of a local traumatic event to the upper lip, presumably causing marked bradykinin release in a patient who was taking an ACE-inhibitor. The local release of bradykinin from trauma, in addition to decreased bradykinin catabolism secondary to ACE-inhibitor therapy resulted in angioedema predominantly in the upper lip. The angioedema resolved with discontinuation of the ACE-inhibitor.