Angioedema is a side effect that is often associated with use of angiotensin converting enzyme inhibitor medications. These medications result in increased levels of circulating bradykinins. This case illustrates the result of a local traumatic event to the upper lip, presumably causing marked bradykinin release in a patient who was taking an ACE-inhibitor. The local release of bradykinin from trauma, in addition to decreased bradykinin catabolism secondary to ACE-inhibitor therapy resulted in angioedema predominantly in the upper lip. The angioedema resolved with discontinuation of the ACE-inhibitor.
Recommended CitationSimmons, B. B.; Folsom, Michelle A.; Bryden, L.eslie A.; and Studdiford, James, "Angioedema after local trauma in a patient on angiotensin-converting enzyme inhibitor therapy" (2008). Department of Family & Community Medicine Faculty Papers. Paper 15.