Document Type

Article

Publication Date

9-8-2025

Comments

This article is the author’s final published version in Neurobiology of Disease, Volume 215, 2025, Article number 107089.

The published version is available at https://doi.org/10.1016/j.nbd.2025.107089. Copyright © 2025 The Authors.

Abstract

Temporal lobe epilepsy (TLE) patients experience shifts between non-seizing and seizing brain states, but the structural networks underlying these transitions remain undefined and poorly characterized. We detected dynamic brain states in resting-state fMRI and constructed linked structural networks utilizing multi-shell diffusion-weighted MR data. Leveraging network control theory, we interrogated the structural data for all possible brain state transitions, identifying those requiring abnormal levels of transition energy (low or high) in TLE compared to matched healthy participants (n's = 25). Results revealed three transitions requiring significantly higher energy in TLE; no abnormally low-energy transitions were observed. In HPs, transitions relied on mediator regions that did not belong to the initial source or final target brain areas. TLE transitions involved a more restricted set of source/target regions, predominantly outside the epileptogenic temporal lobe. Our findings highlight the abnormal and inefficient network mechanisms that accrue from the network entrainment inherent to TLE seizure activity. We argue these findings clarify the pathologic effects and help explain the well-known cognitive inefficiencies and other deficits found in the TLE disorder.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Additional Files
Appendix A. Supplementary data.docx (47 kB)

PubMed ID

40930431

Language

English

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