Document Type
Article
Publication Date
9-2-2019
Abstract
Surgical resection is an important avenue for cancer treatment, which, in most cases, can effectively alleviate the patient symptoms. However, accumulating evidence has documented that surgical resection potentially enhances metastatic seeding of tumor cells. In this review, we revisit the literature on surgical stress, and outline the mechanisms by which surgical stress, including ischemia/reperfusion injury, activation of sympathetic nervous system, inflammation, systemically hypercoagulable state, immune suppression and effects of anesthetic agents, promotes tumor metastasis. We also propose preventive strategies or resolution of tumor metastasis caused by surgical stress.
Recommended Citation
Chen, Zhiwei; Zhang, Peidong; Xu, Ya; Yan, Jiahui; Liu, Zixuan; Lau, Wayne Bond; Lau, Bonnie; Li, Ying; Zhao, Xia; Wei, Yuquan; and Zhou, Shengtao, "Surgical stress and cancer progression: the twisted tango." (2019). Department of Emergency Medicine Faculty Papers. Paper 93.
https://jdc.jefferson.edu/emfp/93
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
31477121
Language
English
Comments
This article has been peer reviewed. It is the author’s final published version in Molecular Cancer, Volume 18, Issue 1, September 2019, Article number 132.
The published version is available at https://doi.org/10.1186/s12943-019-1058-3. Copyright © Chen et al.