Adiponectin at Physiologically Relevant Concentrations Enhances the Vasorelaxative Effect of Acetylcholine via Cav-1/AdipoR-1 Signaling.

Authors

Yunhui Du, Thomas Jefferson UniversityFollow
Rui Li, Shanxi Medical University
Wayne Bond Lau, Thomas Jefferson UniversityFollow
Jianli Zhao, Thomas Jefferson UniversityFollow
Bernard Lopez, Thomas Jefferson UniversityFollow
Theodore A Christopher, Thomas Jefferson UniversityFollow
Xin-Liang Ma, Thomas Jefferson UniversityFollow
Yajing Wang, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

3-2016

Comments

This article has been peer reviewed. It is the author’s final published version in PLoS ONE, Volume 11, Issue 3, March 2016, Article number e0152247.

The published version is available at DOI: 10.1371/journal.pone.0152247. Copyright © Public Library of Science

Abstract

Clinical studies have identified hypoadiponectinemia as an independent hypertension risk factor. It is known that adiponectin (APN) can directly cause vasodilation, but the doses required exceed physiologic levels several fold. In the current study, we determine the effect of physiologically relevant APN concentrations upon vascular tone, and investigate the mechanism(s) responsible. Physiologic APN concentrations alone induced no significant vasorelaxation. Interestingly, pretreatment of wild type mouse aortae with physiologic APN levels significantly enhanced acetylcholine (ACh)-induced vasorelaxation (P

Recommended Citation

Du, Yunhui; Li, Rui; Lau, Wayne Bond; Zhao, Jianli; Lopez, Bernard; Christopher, Theodore A; Ma, Xin-Liang; and Wang, Yajing, "Adiponectin at Physiologically Relevant Concentrations Enhances the Vasorelaxative Effect of Acetylcholine via Cav-1/AdipoR-1 Signaling." (2016). Department of Emergency Medicine Faculty Papers. Paper 43.
https://jdc.jefferson.edu/emfp/43

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

27023866