Background: While prior work examining severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern focused on hospitalization and death, less is known about differences in clinical presentation. We compared the prevalence of acute symptoms across pre-Delta, Delta, and Omicron.
Methods: We conducted an analysis of the Innovative Support for Patients with SARS-CoV-2 Infections Registry (INSPIRE), a cohort study enrolling symptomatic SARS-CoV-2-positive participants. We determined the association between the pre-Delta, Delta, and Omicron time periods and the prevalence of 21 coronavirus disease 2019 (COVID-19) acute symptoms.
Results: We enrolled 4113 participants from December 2020 to June 2022. Pre-Delta vs Delta vs Omicron participants had increasing sore throat (40.9%, 54.6%, 70.6%;
Conclusions: Participants infected during Omicron were more likely to report symptoms of common respiratory viruses, such as sore throat, and less likely to report loss of smell and taste.
Trial Registration: NCT04610515.
Wang, Ralph C,; Gottlieb, Michael; Montoy, Juan Carlos C.; Rodriguez, Robert M.; Yu, Huihui; Spatz, Erica S.; Chandler, Christopher W.; Elmore, Joann G.; Hannikainen, Paavali A.; Chang, Anna Marie; Hill, Mandy; Huebinger, Ryan M.; Idris, Ahamed H.; Koo, Katherine; Li, Shu-Xia; McDonald, Samuel; Nichol, Graham; O'Laughlin, Kelli N.; Plumb, Ian D.; Santangelo, Michelle; Saydah, Sharon; Stephens, Kari A.; Venkatesh, Arjun K.; and Weinstein, Robert A., "Association Between SARS-CoV-2 Variants and Frequency of Acute Symptoms: Analysis of a Multi-institutional Prospective Cohort Study-December 20, 2020-June 20, 2022." (2023). Department of Emergency Medicine Faculty Papers. Paper 227.
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