Francesca L Beaudoin, Brown University
Xinming An, University of North Carolina at Chapel Hill
Archana Basu, Harvard University
Yinyao Ji, University of North Carolina at Chapel Hill
Mochuan Liu, University of North Carolina at Chapel Hill
Ronald C Kessler, Harvard Medical School
Robert F Doughtery, Mindstrong Health
Donglin Zeng, University of North Carolina, Chapel Hill
Kenneth A Bollen, University of North Carolina at Chapel Hill
Stacey L House, Washington University School of Medicine
Jennifer S Stevens, Emory University School of Medicine
Thomas C Neylan, University of California San Francisco
Gari D Clifford, Emory University School of Medicine
Tanja Jovanovic, Wayne State University
Sarah D Linnstaedt, University of North Carolina at Chapel Hill
Laura T Germine, Harvard Medical School
Scott L Rauch, McLean Hospital
John P Haran, University of Massachusetts Medical School
Alan B Storrow, Vanderbilt University Medical Center
Christopher Lewandowski, Henry Ford Health System
Paul I Musey, Indiana University School of Medicine
Phyllis L Hendry, University of Florida College of Medicine
Sophia Sheikh, University of Florida College of Medicine
Christopher W Jones, Cooper Medical School of Rowan University
Brittany E Punches, University of Cincinnati
Michael C Kurz, University of Alabama School of Medicine
Robert A Swor, Oakland University William Beaumont School of Medicine
Vishnu P Murty, Temple University
Meghan E McGrath, Boston Medical Center
Lauren A Hudak, Emory University School of Medicine
Jose L Pascual, University of Pennsylvania
Elizabeth M Datner, Thomas Jefferson UniversityFollow
Anna Marie Chang, Thomas Jefferson UniversityFollow
Claire Pearson, Wayne State University
David A Peak, Massachusetts General Hospital
Roland C Merchant, Brigham and Women's Hospital
Robert M Domeier, Saint Joseph Mercy Hospital
Niels K Rathlev, University of Massachusetts Medical School
Brian J O' Neil, Wayne State University
Paulina Sergot, University of Texas Health
Leon D Sanchez, Harvard Medical School
Steven E Bruce, University of Missouri
Justin T Baker, Mindstrong Health
Jutta Joormann, Yale University
Mark W Miller, Boston University School of Medicine
Robert H Pietrzak, Yale School of Medicine
Deanna M Barch, Washington University in St. Louis
Diego A Pizzagalli, Harvard Medical School
John F Sheridan, OSU Wexner Medical Center
Jordan W Smoller, Massachusetts General Hospital
Steven E Harte, University of Michigan Medical School
James M Elliott, University of Sydney
Karestan C Koenen, Harvard University
Kerry J Ressler, Harvard Medical School
Samuel A McLean, University of North Carolina at Chapel Hill

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This article is the author’s final published version in Translational Psychiatry, Volume 13, Issue 1, January 2023, Article number 4.

The published version is available at Copyright © Beaudoin et al.


The authors sought to characterize adverse posttraumatic neuropsychiatric sequelae (APNS) symptom trajectories across ten symptom domains (pain, depression, sleep, nightmares, avoidance, re-experiencing, anxiety, hyperarousal, somatic, and mental/fatigue symptoms) in a large, diverse, understudied sample of motor vehicle collision (MVC) survivors. More than two thousand MVC survivors were enrolled in the emergency department (ED) and completed a rotating battery of brief smartphone-based surveys over a 2-month period. Measurement models developed from survey item responses were used in latent growth curve/mixture modeling to characterize homogeneous symptom trajectories. Associations between individual trajectories and pre-trauma and peritraumatic characteristics and traditional outcomes were compared, along with associations within and between trajectories. APNS across all ten symptom domains were common in the first two months after trauma. Many risk factors and associations with high symptom burden trajectories were shared across domains. Both across and within traditional diagnostic boundaries, APNS trajectory intercepts, and slopes were substantially correlated. Across all domains, symptom severity in the immediate aftermath of trauma (trajectory intercepts) had the greatest influence on the outcome. An interactive data visualization tool was developed to allow readers to explore relationships of interest between individual characteristics, symptom trajectories, and traditional outcomes ( ). Individuals presenting to the ED after MVC commonly experience a broad constellation of adverse posttraumatic symptoms. Many risk factors for diverse APNS are shared. Individuals diagnosed with a single traditional outcome should be screened for others. The utility of multidimensional categorizations that characterize individuals across traditional diagnostic domains should be explored.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

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