Document Type
Article
Publication Date
6-30-2022
Abstract
Coronary microvascular dysfunction (CMD) refers to a subset of structural and/or functional disorders of coronary microcirculation that lead to impaired coronary blood flow and eventually myocardial ischemia. Amid the growing knowledge of the pathophysiological mechanisms and the development of advanced tools for assessment, CMD has emerged as a prevalent cause of a broad spectrum of cardiovascular diseases (CVDs), including obstructive and nonobstructive coronary artery disease, diabetic cardiomyopathy, and heart failure with preserved ejection fraction. Of note, the endothelium exerts vital functions in regulating coronary microvascular and cardiac function. Importantly, insufficient or uncontrolled activation of endothelial autophagy facilitates the pathogenesis of CMD in diverse CVDs. Here, we review the progress in understanding the pathophysiological mechanisms of autophagy in coronary endothelial cells and discuss their potential role in CMD and CVDs.
Recommended Citation
Zhao, Fujie; Satyanarayana, Ganesh; Zhang, Zheng; Zhao, Jianli; Ma, Xin-Liang; and Wang, Yajing, "Endothelial Autophagy in Coronary Microvascular Dysfunction and Cardiovascular Disease" (2022). Department of Emergency Medicine Faculty Papers. Paper 202.
https://jdc.jefferson.edu/emfp/202
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
35805165
Language
English
Comments
This article is the author's final published version in Cells, Volume 11, Issue 13, July 2022, Article number 2081.
The published version is available at https://doi.org/10.3390/cells11132081.
Copyright © 2022 by the authors.
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).