C1q/tumor necrosis factor-related protein-3, a newly identified adipokine, is a novel antiapoptotic, proangiogenic, and cardioprotective molecule in the ischemic mouse heart.

Authors

Wei Yi, Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University; Department of Emergency Medicine, Thomas Jefferson UniversityFollow
Yang Sun, Department of Geriatrics, Xijing Hospital, Fourth Military Medical University; Department of Emergency Medicine, Thomas Jefferson UniversityFollow
Yuexing Yuan, Department of Emergency Medicine, Thomas Jefferson UniversityFollow
Wayne Bond Lau, Department of Emergency Medicine, Thomas Jefferson UniversityFollow
Qijun Zheng, Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University; Department of Emergency Medicine, Thomas Jefferson UniversityFollow
Xiaoliang Wang, Department of Emergency Medicine, Thomas Jefferson UniversityFollow
Yajing Wang, Department of Emergency Medicine, Thomas Jefferson UniversityFollow
Xiying Shang, Center for Translational Medicine, Temple University Medical SchoolFollow
Erhe Gao, Center for Translational Medicine, Temple University Medical SchooFollow
Walter J Koch, Center for Translational Medicine, Temple University Medical SchooFollow
Xin-Liang Ma, Department of Emergency Medicine, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

6-26-2012

Comments

This article has been peer reviewed and is published in Circulation.

Volume 125, Issue 25, 26 June 2012, Pages 3159-3169

The published version is available at DOI: 10.1161/CIRCULATIONAHA.112.099937. © 2012 American Heart Association, Inc.

Abstract

BACKGROUND: Obesity and diabetes mellitus adversely affect postischemic heart remodeling via incompletely understood mechanisms. C1q/tumor necrosis factor-related protein-3 (CTRP3) is a newly identified adipokine exerting beneficial metabolic regulation, similar to adiponectin. The aim of the present study was to determine whether CTRP3 may regulate postischemic cardiac remodeling and cardiac dysfunction, and, if so, to elucidate the underlying mechanisms.

METHODS AND RESULTS: Male adult mice were subjected to myocardial infarction (MI) via left anterior descending coronary artery occlusion. Both the effect of MI on endogenous CTRP3 expression/production and the effect of exogenous CTRP3 (adenovirus or recombinant CTRP3) replenishment on MI injury were investigated. MI significantly inhibited adipocyte CTRP3 expression and reduced the plasma CTRP3 level, reaching a nadir 3 days after MI. CTRP3 replenishment improved survival rate (P

CONCLUSION: CTRP3 is a novel antiapoptotic, proangiogenic, and cardioprotective adipokine, the expression of which is significantly inhibited after MI.

Recommended Citation

Yi, Wei; Sun, Yang; Yuan, Yuexing; Lau, Wayne Bond; Zheng, Qijun; Wang, Xiaoliang; Wang, Yajing; Shang, Xiying; Gao, Erhe; Koch, Walter J; and Ma, Xin-Liang, "C1q/tumor necrosis factor-related protein-3, a newly identified adipokine, is a novel antiapoptotic, proangiogenic, and cardioprotective molecule in the ischemic mouse heart." (2012). Department of Emergency Medicine Faculty Papers. Paper 20.
https://jdc.jefferson.edu/emfp/20

PubMed ID

22653084