The Protective Effect of Traditional Chinese Medicine on Liver Ischemia-Reperfusion Injury.

Authors

Wen Ma, Sichuan University-The Hong Kong Polytechnic University Institute for Disaster Management and Reconstruction, Chengdu 610207, China; Research Laboratory of Emergency Medicine, Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu 610041, China
Songling Tang, Research Laboratory of Emergency Medicine, Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu 610041, China
Dina Xie, Department of Emergency Medicine, Thomas Jefferson University, Philadelphia 19107, PA, USAFollow
Guoqiang Gu, Cardiology Department, Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China
Lu Gan, Research Laboratory of Emergency Medicine, Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu 610041, China; National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China

Document Type

Article

Publication Date

4-8-2021

Comments

This article is the author's final published version in Evidence-based Complementary and Alternative Medicine, Volume 2021, 2021, Article number 5564401.

The published version is available at https://doi.org/10.1155/2021/5564401

Copyright © 2021 Wen Ma et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Liver ischemia-reperfusion (I/R) injury occurs during transplantation and major hepatic surgery, which may lead to postoperative liver dysfunction. More and more traditional Chinese medicines (TCMs) have been used to treat liver ischemia-reperfusion injury. The purpose of this review is to evaluate the different protective effects of TCMs in the treatment of liver ischemia-reperfusion injury and to summarize its possible mechanisms. The results indicate that TCMs attenuate liver I/R injury via multiple mechanisms, including antioxidation stress, anti-inflammatory response, antiapoptosis, and inhibiting endoplasmic reticulum stress. However, the in-depth mechanism of the protective effects of these traditional Chinese medicines still remains unknown.

Recommended Citation

Ma, Wen; Tang, Songling; Xie, Dina; Gu, Guoqiang; and Gan, Lu, "The Protective Effect of Traditional Chinese Medicine on Liver Ischemia-Reperfusion Injury." (2021). Department of Emergency Medicine Faculty Papers. Paper 136.
https://jdc.jefferson.edu/emfp/136

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

33927775

Language

English