Document Type
Article
Publication Date
2-15-2023
Abstract
Immune-related cutaneous adverse events (ircAE) are commonly seen with immune checkpoint inhibitors such as atezolizumab. Atezolizumab-induced psoriasis has been previously reported as an ircAE, especially in patients with pre-existing psoriasis. The severity of the reaction influences treatment of the cutaneous eruption. Biologics should be considered as a treatment option for severe refractory psoriasiform eruptions even in patients with complex medical conditions like chronic infections and malignancy. This is the first reported case of successful treatment of atezolizumab-induced psoriasiform eruption with ixekizumab, a neutralizing IL17A monoclonal antibody, to the best of our knowledge. Herein, we present a 63-year-old man with a history of human immunodeficiency virus and psoriasis who presented with atezolizumab-induced psoriasiform eruption while being treated for metastatic hepatocellular carcinoma. After initiating ixekizumab, atezolizumab was restarted without cutaneous eruption.
Recommended Citation
Gleason, Laura; Hunter, E; Cohen, Alexa J.; Suriano, Jayson; and Nikbakht, Neda, "Atezolizumab-Induced Psoriasiform Drug Eruption Successfully Treated with Ixekizumab: A Case Report and Literature Review" (2023). Department of Dermatology and Cutaneous Biology Faculty Papers. Paper 179.
https://jdc.jefferson.edu/dcbfp/179
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
PubMed ID
37040912
Language
English
Comments
This article is the author's final published version in Dermatology Online Journal, Voume 29, Issue 1, 2023, Article number 9.
The published version is available at https://doi.org/10.5070/D329160215.
Copyright © 2023 by the author(s).