Consistency of HFrEF Treatment Effect in Underrepresented Groups in Randomized Clinical Trials

Authors

• Guillaume Baudry
• Luca Monzo
• Mark C. Petrie
• Nicolas Girerd
• Iliana L Piña, Thomas Jefferson UniversityFollow
• Alexandre Mebazaa
• Javed Butler
• Leila Abid
• Faiez Zannad
• Harriette G.C. Van Spall

Document Type

Article

Publication Date

2-3-2025

Comments

This article is the author's final published version in npj Cardiovascular Health, Volume 2, Issue 1, 2025, Article Number 6.

The published version is available at https://doi.org/10.1038/s44325-025-00045-x. Copyright © The Author(s) 2025.

Abstract

Despite the established efficacy of heart failure (HF) guideline-directed medical therapies, implementation varies across demographic groups, including Black, Indigenous, and people of color, older adults, females, and those who are socioeconomically deprived. This review synthesizes the representativeness of trial participants and describes subgroup analyses from pivotal trials in HF with reduced ejection fraction (HFrEF). It reviews the largely consistent treatment effect of medical therapies across the demographic groups represented in trials. It makes arguments for broad implementation of therapies based on these data, while calling for more representative trials to improve research and health equity in HF.

Recommended Citation

Baudry, Guillaume; Monzo, Luca; Petrie, Mark C.; Girerd, Nicolas; Piña, Iliana L; Mebazaa, Alexandre; Butler, Javed; Abid, Leila; Zannad, Faiez; and Van Spall, Harriette G.C., "Consistency of HFrEF Treatment Effect in Underrepresented Groups in Randomized Clinical Trials" (2025). Division of Cardiology Faculty Papers. Paper 203.
https://jdc.jefferson.edu/cardiologyfp/203

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

Language

English

PubMed ID

41776334