Risk of Coronary Artery Disease in Patients With Gout on Treatment With Colchicine: A Systematic Review and Meta-Analysis
Background: Colchicine has anti-inflammatory properties, but its utility in improving cardiovascular outcomes has been disputed. Here, we study the impact of colchicine on cardiovascular outcomes in patients with gout with and without coronary artery disease (CAD).
Methods: Medline, Web of Science and Cochrane Central Register of Controlled Trials were systematically searched to identify relevant studies. Primary outcomes included myocardial infarction (MI), percutaneous coronary intervention (PCI), and coronary artery bypass grafting (CABG). Secondary outcomes included stroke and all-cause mortality.
Results: We included 4 observational studies comprising 10,026 patients with gout on treatment with colchicine. There was no significant difference in the risk of myocardial infarction (risk ratio [RR] 0.71; 95% confidence interval [CI], 0.36-1.39), need for PCI, or need for CABG, between patients on colchicine and those not receiving colchicine. Colchicine was associated with a significantly lower risk of all-cause mortality (RR 0.58; 95% CI 0.43-0.79).
Conclusion: Non-randomized studies suggest that risk of MI, stroke and revascularization is not higher in gout patients treated with colchicine compared to gout patients without colchicine treatment.
Siddiqui, Muhammad U; Junarta, Joey; Sathyanarayanan, Swaminathan; Kochar, Kirpal; Ullah, Waqas; and Fischman, D L, "Risk of Coronary Artery Disease in Patients With Gout on Treatment With Colchicine: A Systematic Review and Meta-Analysis" (2023). Division of Cardiology Faculty Papers. Paper 118.
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This article is the author’s final published version in IJC Heart and Vasculature, Volume 45, March 2023, Article number 101191
The published version is available at https://doi.org/10.1016/j.ijcha.2023.101191. Copyright © Siddiqui et al.