Document Type
Article
Publication Date
8-3-2022
Abstract
We aimed to identify a simple metric accounting for peri-procedural hemoglobin changes, independent of blood product transfusion strategies, and assess its correlation with outcomes in patients undergoing left ventricular assist device (LVAD) implantation We included consecutive patients undergoing LVAD implantation at a single center between 10/1/2008 and 6/1/2014. The anemia stress index (ASI), defined as the sum of number of packed red blood cells transfused and the hemoglobin changes after LVAD implantation, was calculated for each patient at 24 h, discharge, and 3 months after LVAD implantation. Our cohort included 166 patients (80.1% males, mean age 56.3 ± 15.6 years) followed up for a median of 12.3 months. Increases in ASI per unit were associated with a higher hazard for all-cause mortality and early RV failure. The associations between the ASI and all-cause mortality persisted after multivariable adjustment, irrespective of when it was calculated (adjusted HR of 1.11, 95% CI 1.03-1.20 per unit increase in ASI). Similarly, ASI at 24 h after implant was associated with early RV failure despite multivariable adjustment (OR 1.09, 95% CI 1.05-1.14). We present a novel metric, the ASI, that is correlated with an increased risk for all-cause mortality and early RV failure in LVAD recipients.
Recommended Citation
Shore, Supriya; Hanff, Thomas C; Mazurek, Jeremy A; Fox, Arieh; Tanna, Monique S; Grandin, Edward W; Zhang, Robert; Wald, Joyce; Peters, Carli; Acker, Michael A; Atluri, Pavan; Rame, J Eduardo; Goldberg, Lee R; Jessup, Mariell; Margulies, Kenneth B; and Birati, Edo Y, "The Anemia Stress Index-Anemia, Transfusions, and Mortality in Patients with Continuous Flow Ventricular Assist Devices" (2022). Division of Cardiology Faculty Papers. Paper 104.
https://jdc.jefferson.edu/cardiologyfp/104
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Language
English
PubMed ID
35956132
Comments
This article is the author's final published version in Journal of Clinical Medicine, Volume 11, Issue 15, August 2022, Article number 4517.
The published version is available at https://doi.org/10.3390/jcm11154517.
Copyright © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).