Document Type
Article
Publication Date
5-5-2023
Abstract
Protease-activated receptors (PARs) are a class of integral membrane proteins that are cleaved by a variety of proteases, most notably thrombin, to reveal a tethered ligand and promote activation. PARs are critical mediators of platelet function in hemostasis and thrombosis, and therefore are attractive targets for anti-platelet therapies. Animal models studying platelet PAR physiology have relied heavily on genetically modified mouse strains, which have provided ample insight but have some inherent limitations. The current review aims to summarize the notable PAR expression and functional differences between the mouse and human, in addition to highlighting some recently developed tools to further study human physiology in mouse models.
Recommended Citation
Renna, Stephanie A; McKenzie, Steven E.; and Michael, James V., "Species Differences in Platelet Protease-Activated Receptors" (2023). Cardeza Foundation for Hematologic Research. Paper 72.
https://jdc.jefferson.edu/cardeza_foundation/72
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Language
English
Comments
This article is the author's final published version in International Journal of Molecular Sciences, Volume 24, Issue 9, May 2023, Article number 8298.
The published version is available at https://doi.org/10.3390/ijms24098298.
Copyright © 2023 by the authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).