Document Type
Article
Publication Date
3-22-2016
Abstract
BACKGROUND: Recent population-based studies in the United States of America (USA) and other countries have shown improvements in survival for patients with chronic lymphocytic leukemia (CLL) diagnosed in the early twenty-first century. Here, we examine the survival for patients diagnosed with CLL in Germany in 1997-2011.
METHODS: Data were extracted from 12 cancer registries in Germany and compared to the data from the USA. Period analysis was used to estimate 5- and 10-year relative survival (RS).
RESULTS: Five- and 10-year RS estimates in 2009-2011 of 80.2 and 59.5%, respectively, in Germany and 82.4 and 64.7%, respectively, in the USA were observed. Overall, 5-year RS increased significantly in Germany and the difference compared to the survival in the USA which slightly decreased between 2003-2005 and 2009-2011. However, age-specific analyses showed persistently higher survival for all ages except for 15-44 in the USA. In general, survival decreased with age, but the age-related disparity was small for patients younger than 75. In both countries, 5-year RS was >80% for patients less than 75 years of age but
CONCLUSIONS: Overall, 5-year survival for patients with CLL is good, but 10-year survival is significantly lower, and survival was much lower for those age 75+. Major differences in survival between countries were not observed. Further research into ways to increase survival for older CLL patients are needed to reduce the persistent large age-related survival disparity.
Recommended Citation
Pulte, Dianne; Castro, Felipe A; Jansen, Lina; Luttmann, Sabine; Holleczek, Bernd; Nennecke, Alice; Ressing, Meike; Katalinic, Alexander; and Brenner, Hermann, "Trends in survival of chronic lymphocytic leukemia patients in Germany and the USA in the first decade of the twenty-first century." (2016). Cardeza Foundation for Hematologic Research. Paper 32.
https://jdc.jefferson.edu/cardeza_foundation/32
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
This article has been peer reviewed. It was published in: Journal of Hematology and Oncology.
Volume 9, Issue 1, 22 March 2016, Article number 257.
The published version is available at DOI: 10.1186/s13045-016-0257-2
Copyright © Pulte et al. 2016
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