Usefulness of baseline lipids and C-reactive protein in women receiving menopausal hormone therapy as predictors of treatment-related coronary events.

Authors

Paul Bray, Thomas Jefferson UniversityFollow
Joseph C Larson, Fred Hutchinson Cancer Research Center
Andrea Z Lacroix, Fred Hutchinson Cancer Research Center
Joann Manson, Brigham and Women’s Hospital, Harvard Medical School
Marian C Limacher, University of Florida, Gainseville
Jacques E Rossouw, National Heart, Lung and Blood Institute
Norman L Lasser, New Jersey Medical SchoolFollow
William E Lawson, State University of New York
Marcia L Stefanick, Stanford University
Robert D Langer, Geisinger Center for Health Research
Karen L Margolis, University of Minnesota

Document Type

Article

Publication Date

6-2008

Comments

This article has not been peer reviewed. It is the authors' manuscript prior to publication in American Journal of Cardiology, Volume 101, Issue 11, June 2008, Pages 1599–1605.e1.

The published version is available at DOI: 10.1016/j.amjcard.2008.01.043. Copyright © Elsevier

Abstract

Blood lipids and high-sensitivity C-reactive protein (hs-CRP) are altered by hormone therapy. The goal of the present study was to determine whether lipids and hs-CRP have predictive value for hormone therapy benefit or risk for coronary heart disease events in postmenopausal women without previous cardiovascular disease. A nested case-control study was performed in the Women's Health Initiative hormone trials. Baseline lipids and hs-CRP were obtained from 271 incident patients with coronary heart disease (cases) and 707 controls. In a combined trial analysis, favorable lipid status at baseline tended to predict better coronary heart disease outcomes when using conjugated equine estrogen (CEE) with or without medroxyprogesterone acetate (MPA). Women with a low-density lipoprotein (LDL)/high-density lipoprotein (HDL) cholesterol ratioor =2.5 had increased risk of coronary heart disease (odds ratio 1.73, 95% confidence interval 1.18 to 2.53, p for interaction = 0.02). Low hs-CRP added marginally to the value of LDL/HDL ratio

Recommended Citation

Bray, Paul; Larson, Joseph C; Lacroix, Andrea Z; Manson, Joann; Limacher, Marian C; Rossouw, Jacques E; Lasser, Norman L; Lawson, William E; Stefanick, Marcia L; Langer, Robert D; and Margolis, Karen L, "Usefulness of baseline lipids and C-reactive protein in women receiving menopausal hormone therapy as predictors of treatment-related coronary events." (2008). Cardeza Foundation for Hematologic Research. Paper 14.
https://jdc.jefferson.edu/cardeza_foundation/14