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Urokinase Plasminogen Activator Expression is Regulated by p53 Harboring the Lung Cancer-Specific Mutation V157F
Julie Barta, MD; Kristen Pauley; and Steven B. McMahon, PhD
- To define the mutant p53-regulated transcriptome of lung cancer cells with alterations at V157 and R158 in the p53 tumor suppressor.
- To determine the biological effects of lung-enriched p53 mutations in lung cancer cells.