Document Type
Article
Publication Date
6-12-2018
Abstract
Posterior reversible encephalopathy syndrome (PRES) is an increasingly recognizable neuro-clinical syndrome. Clinical and neurological manifestations of PRES include hypertension, headache, encephalopathy, seizures, and symmetrical white matter changes on brain MRI. Most common precipitants of PRES are acute medical illness, hypertensive crisis, eclampsia, immunosuppressive therapy, and chemotherapy. Bevacizumab is a monoclonal antibody that halts angiogenesis by inhibiting vascular endothelial growth factor. It has gained widespread popularity in oncology world especially for metastatic and recurrent cancers due to its inherent ability to stop angiogenesis; a vital step for tumor growth. Bevacizumab has also been implicated as the cause of PRES due to dysregulation of the blood-brain barrier. We are reporting a case of PRES induced by Bevacizumab in a patient of colorectal cancer.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Recommended Citation
Hamid, Mohsin; Ghani, Ali; Micaily, Ida; Sarwar, MD, Usman; Lashari, MD, Bilal; and Malik, Faizan, "Posterior reversible encephalopathy syndrome (PRES) after bevacizumab therapy for metastatic colorectal cancer." (2018). Abington Jefferson Health Papers. Paper 3.
https://jdc.jefferson.edu/abingtonfp/3
PubMed ID
29915651
Language
English
Comments
This article has been peer reviewed. It is the author’s final published version in Journal of Community Hospital Internal Medicine Perspectives , Volume 8, Issue 3, June 2018, Pages 130-133.
The published version is available at https://doi.org/10.1080/20009666.2018.1478563. Copyright © Hamid et al.