Document Type
Article
Publication Date
7-16-2019
Abstract
Granulomatosis with polyangiitis (GPA) is a systemic granulomatous inflammatory disease characterized by small-to-medium vessel vasculitis due to Central Anti-Neutrophil Cytoplasmic Antibody (C-ANCA). GPA commonly involves the lungs and the kidneys. Among the pulmonary manifestations, diffuse alveolar hemorrhage (DHA) is a rare presentation of GPA that can present with hemoptysis leading to acute onset of anemia and hemodynamic instability. An active diagnostic workup including serologic titer of C-ANCA, imaging, intensive care, and aggressive immunosuppression is the key to DAH management. We report a case of DAH secondary to GPA that presented with hemoptysis leading to severe anemia, initially resuscitated symptomatically and started on plasmapheresis with pulse steroids and cyclophosphamide. Timely diagnosis and management led to a remarkable recovery of the pulmonary symptoms and imaging findings of DAH.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Sattar, Yasar; Susheela, Ammu Thampi; Ullah, Waqas; Usman, Norina; and Zafrullah, Fnu, "Use of Plasmapheresis and Immunosuppressants to Treat Diffuse Alveolar Hemorrhage in a Patient with Granulomatosis with Polyangiitis." (2019). Abington Jefferson Health Papers. Paper 13.
https://jdc.jefferson.edu/abingtonfp/13
PubMed ID
31315254
Language
English
Comments
This article has been peer reviewed. It is the author’s final published version in Medicina (Lithuania), Volume 55, Issue 7, July 2019, Article number 378.
The published version is available at https://doi.org/10.3390/medicina55070378. Copyright © Sattar et al.