Document Type
Article
Publication Date
8-1-2024
Abstract
Propafenone is a class 1C antiarrhythmic and is one of the first-line drugs used in the management of atrial fibrillation. Its toxicity is rare, yet potentially life-threatening. Common clinical findings could range from hypotension, dysrhythmias, and conduction disturbances to cardiac arrest. We present a case of an 80-year-old male who presented with generalized weakness and polyuria secondary to over-diuresis leading to dehydration. Electrocardiogram on admission showed a first-degree atrioventricular block, QRS complex widening, and QTC interval prolongation. These findings were attributed to propafenone toxicity in the setting of dehydration and increased serum propafenone concentration. In the case described the optimization of fluid status and holding propafenone temporarily led to rapid reversal of the electrocardiogram changes. Multiple treatment modalities have been attempted, but standard recommendations for propafenone toxicity management have yet to be established. This case stresses the importance of taking into consideration volume status and other reversible risk factors possibly contributing to propafenone toxicity.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Haddad, Enad and Collins, Matthew, "A Case of Propafenone Toxicity in the Setting of Dehydration and Acute Kidney Injury" (2024). Abington Jefferson Health Papers. Paper 109.
https://jdc.jefferson.edu/abingtonfp/109
Language
English
Comments
This article is the author's final published version in Global Cardiology Science and Practice, Volume 2024, Issue 4, August 2024, Article number 38.
The published version is available at https://doi.org/10.21542/gcsp.2024.38.
Copyright © 2024 The Author(s).