Document Type
Article
Publication Date
1-1-2008
Abstract
The nuclear factor-kappa B family of transcription factors is intimately involved in the regulation of the inflammatory responses that play a fundamental role in the damage of articular tissues. Thus, many studies have examined the important contributions of components of the NF-kappaB signaling pathways to the pathogenesis of various rheumatic diseases and their pharmacologic modulation. Currently available therapeutic agents including nonsteroidal anti-inflammatory drugs, corticosteroids, nutraceuticals, and disease-modifying antirheumatic drugs, as well as novel specific small-molecule inhibitors have been employed. In addition, promising nucleic acid-based strategies have shown encouraging results. However, further research will be needed before NF-kappaB-aimed strategies become an effective therapy for inflammatory arthritis.
Recommended Citation
Roman-Blas, Jorge A. and Jimenez, Sergio A., "Targeting NF-kappaB: a promising molecular therapy in inflammatory arthritis." (2008). Scleroderma Center Faculty Papers. Paper 1.
https://jdc.jefferson.edu/sclerodermafp/1
PubMed ID
18853343
Comments
This article has been peer reviewed. It is the authors' final version prior to publication in International Reviews of Immunology Volume 27, Issue 5, September 2008, Pages 351-374. The published version is available at . DOI: 10.1080/08830180802295740. Copyright © informaworld.