Calibration of a Novel Microdosimetry System for In Vitro Applications of Actinide Radiopharmaceuticals

Authors

Lydia J. Wilson, Thomas Jefferson UniversityFollow
Brian Miller, The University of Arizona
George Tabatadze, Washington State University
Firas Mourtada, Thomas Jefferson UniversityFollow

Files

Description

Background

• Alpha-emitting radionuclides show promise for targeted radiopharmaceutical therapy (TRT).
• High linear energy transfer and short range cause highly localized DNA damage for effective cancer cell eradication.
• However, distributions of radioactivity and absorbed dose on the cellular scale remain elusive.
• Progress toward understanding α-TRT radiobiologic response, evaluating novel α-TRT drug efficacy, and optimizing administration for personalized treatments will require knowledge of radioactivity and absorbed dose distributions.
• A novel real-time α camera, the ionizing radiation quantum imaging detector (iQID), has successfully mapped the microdistribution of α-emitting radionuclides in mouse and human tissues [1].

Publication Date

9-3-2024

Keywords

microdosimetry, radiopharmaceutical therapy, alpha particles

Disciplines

Medicine and Health Sciences | Oncology | Radiology

Comments

Presented at the 2024 Annual Meeting of the Radiation Research Society.

Recommended Citation

Wilson, Lydia J.; Miller, Brian; Tabatadze, George; and Mourtada, Firas, "Calibration of a Novel Microdosimetry System for In Vitro Applications of Actinide Radiopharmaceuticals" (2024). Department of Radiation Oncology Posters. 4.
https://jdc.jefferson.edu/radoncposters/4