A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer.

Authors

Scott A Waldman, Thomas Jefferson UniversityFollow
Andre Terzic, Mayo ClinicFollow

Document Type

Article

Publication Date

4-1-2009

Comments

This article has been peer reviewed. It is the authors' final version prior to publication in FEBS Journal

Volume 276, Issue 8, April 2009, Pages 2157-2164.

The published version is available at DOI: 10.1111/j.1742-4658.2009.06934.x. Copyright © John Wiley & Sons, Inc.

Abstract

There is emerging evidence of the production in human tumors of abnormal levels of microRNAs (miRNAs), which have been assigned oncogenic and/or tumor-suppressor functions. While some miRNAs commonly exhibit altered amounts across tumors, more often, different tumor types produce unique patterns of miRNAs, related to their tissue of origin. The role of miRNAs in tumorigenesis underscores their value as mechanism-based therapeutic targets in cancer. Similarly, unique patterns of altered levels of miRNA production provide fingerprints that may serve as molecular biomarkers for tumor diagnosis, classification, prognosis of disease-specific outcomes and prediction of therapeutic responses.

Recommended Citation

Waldman, Scott A and Terzic, Andre, "A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer." (2009). Department of Pharmacology and Experimental Therapeutics Faculty Papers. Paper 31.
https://jdc.jefferson.edu/petfp/31

PubMed ID

19250312