A Review of IsomiRs in Colorectal Cancer

Authors

Molly A. Lausten
Bruce M. Boman, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

6-7-2023

Comments

This article is the author's final published version in Non-coding RNA, Volume 9, Issue 3, Article number 34.

The published version is available at https://doi.org/10.3390/ncrna9030034. Copyright © © 2023 by the authors. Licensee MDPI, Basel, Switzerland.

Abstract

As advancements in sequencing technology rapidly continue to develop, a new classification of microRNAs has occurred with the discovery of isomiRs, which are relatively common microRNAs with sequence variations compared to their established template microRNAs. This review article seeks to compile all known information about isomiRs in colorectal cancer (CRC), which has not, to our knowledge, been gathered previously to any great extent. A brief overview is given of the history of microRNAs, their implications in colon cancer, the canonical pathway of biogenesis and isomiR classification. This is followed by a comprehensive review of the literature that is available on microRNA isoforms in CRC. The information on isomiRs presented herein shows that isomiRs hold great promise for translation into new diagnostics and therapeutics in clinical medicine.

Recommended Citation

Lausten, Molly A. and Boman, Bruce M., "A Review of IsomiRs in Colorectal Cancer" (2023). Department of Pharmacology and Experimental Therapeutics Faculty Papers. Paper 152.
https://jdc.jefferson.edu/petfp/152

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

Language

English