Authors

Shennan Aibel Weiss, University of California Los Angeles
Ali Akbar Asadi-Pooya, Thomas Jefferson UniversityFollow
Sitaram Vangala, University of California Los Angeles
Stephanie Moy, University of California Los Angeles
Dale H. Wyeth, Thomas Jefferson UniversityFollow
Iren Orosz, University of California Los Angeles
Michael Gibbs, University of California Los Angeles
Lara Schrader, University of California Los Angeles
Jason Lerner, University of California Los Angeles
Christopher K Cheng, University of California Los Angeles
Edward Chang, University of California Los Angeles
Rajsekar Rajaraman, University of California Los Angeles
Inna Keselman, University of California Los Angeles
Perdro Churchman, University of California Los Angeles
Christine Bower-Baca, University of California Los Angeles
Adam L Numis, University of California Los Angeles
Michael G Ho, University of California Los Angeles
Lekha Rao, University of California Los Angeles
Annapoorna Bhat, Thomas Jefferson UniversityFollow
Joanna Suski, Thomas Jefferson UniversityFollow
Marjan Asadollahi, Thomas Jefferson UniversityFollow
Timothy Ambrose, Thomas Jefferson UniversityFollow
Andres Fernandez, Thomas Jefferson UniversityFollow
Maromi Nei, Thomas Jefferson UniversityFollow
Christopher T. Skidmore, Thomas Jefferson UniversityFollow
Scott Mintzer, Thomas Jefferson UniversityFollow
Dawn S. Eliashiv, Thomas Jefferson University
Gary W Mathern, University of California Los Angeles
Marc R Nuwer, University of California Los Angeles
Michael R. Sperling, Thomas Jefferson UniversityFollow
Jerome Engel, University of California Los Angeles
John M Stern, University of California Los Angeles

Document Type

Article

Publication Date

4-4-2017

Comments

This article has been peer reviewed. It is the author’s final published version in F1000Research

Volume 6, April 2017, Article number 30

The published version is available at DOI: 10.12688/f1000research.10569.2. Copyright © Weiss et al.

Abstract

Objective: To develop a novel software method (AR2) for reducing muscle contamination of ictal scalp electroencephalogram (EEG), and validate this method on the basis of its performance in comparison to a commercially available software method (AR1) to accurately depict seizure-onset location. Methods: A blinded investigation used 23 EEG recordings of seizures from 8 patients. Each recording was uninterpretable with digital filtering because of muscle artifact and processed using AR1 and AR2 and reviewed by 26 EEG specialists. EEG readers assessed seizure-onset time, lateralization, and region, and specified confidence for each determination. The two methods were validated on the basis of the number of readers able to render assignments, confidence, the intra-class correlation (ICC), and agreement with other clinical findings. Results: Among the 23 seizures, two-thirds of the readers were able to delineate seizure-onset time in 10 of 23 using AR1, and 15 of 23 using AR2 (p

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This work is licensed under a Creative Commons Attribution 4.0 License.

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