Document Type
Article
Publication Date
5-24-2022
Abstract
Without sufficient herd immunity through either vaccination or natural infection, the coronavirus disease 2019 pandemic is unlikely to be controlled. Waning immunity with the currently approved vaccines suggests the need to evaluate vaccines causing the induction of long-term responses. Here, we report the immunogenicity and efficacy of our adjuvanted single-dose Rabies-vectored SARS-CoV-2 S1 vaccine, CORAVAX, in hamsters. CORAVAX induces high SARS-CoV-2 S1-specific and virus-neutralizing antibodies (VNAs) that prevent weight loss, viral loads, disease, lung inflammation, and the cytokine storm in hamsters. We also observed high Rabies VNA titers. In summary, CORAVAX is a promising dual-antigen vaccine candidate for clinical evaluation against SARS-CoV-2 and Rabies virus.
Recommended Citation
Kurup, Drishya; Wirblich, Christoph; Zabihi Diba, Leila; Lambert, Rachael; Watson, Megan; Shaikh, Noor; Ramage, Holly; Solomides, Charalambos; and Schnell, Matthias J, "A Single Dose of the Deactivated Rabies-Virus Vectored COVID-19 Vaccine, CORAVAX, Is Highly Efficacious and Alleviates Lung Inflammation in the Hamster Model" (2022). Department of Microbiology and Immunology Faculty Papers. Paper 158.
https://jdc.jefferson.edu/mifp/158
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
35746597
Language
English
Included in
Medical Immunology Commons, Medical Microbiology Commons, Medical Pathology Commons, Pathology Commons
Comments
This article is the author's final published version in Viruses, Volume 14, Issue 6, June 2022, Article number 1126.
The published version is available at https://doi.org/10.3390/v14061126.
Copyright © 2022 by the authors.
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).