Document Type

Article

Publication Date

5-17-2016

Comments

This article has been peer reviewed. It is the author’s final published version in Oncotarget

Volume 7, Issue 31, May 2016, Pages 50755-50765.

The published version is available at DOI: 10.18632/oncotarget.9394. Copyright © Kong et al.

Abstract

Although originally identified for its function in Drosophila melanogaster eye specification, the Retinal Determination Gene Network (RDGN) is essential for the development of multiple organs in mammals. The RDGN regulates proliferation, differentiation and autocrine signaling, and interacts with other key signaling pathways. Aberrant expression of RDGN members such as DACH, EYA and SIX contributes to tumor initiation and progression; indeed, the levels of RDGN members are clinically prognostic factors in various cancer types. Stimulation or suppression of the activities of these crucial components can block cancer cell proliferation, prevent cancer stem cell expansion and even reverse the EMT process, thereby attenuating malignant phenotypes. Thus, cancer therapeutic interventions targeting RDGN members should be pursued in future studies.

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